Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route
Despite these positive effects of the cyclodextrin, the amount of PPF permeated was minimal in 3 h, exceeding the formulation residence time in the nose. These results highlight the key role of formulation and the need for innovation in solubility and transmucosal transport enhancement techniques to optimize drug delivery and therapeutic efficacy.
Authors
- Michele Domenico Spampinato (ORCID: https://orcid.org/0000-0002-2285-327X)
- Anna Costanzini (ORCID: https://orcid.org/0000-0002-8644-1135)
- Gaia Colombo (ORCID: https://orcid.org/0000-0001-9033-2305)
- Roberto De Giorgio (ORCID: https://orcid.org/0000-0003-0867-5873)
- Sabrina Banella (ORCID: https://orcid.org/0000-0003-2676-1951)
- Fabrizio Bortolotti
- Nicola Realdon (ORCID: https://orcid.org/0000-0001-5624-6876)
- Angelina Passaro (ORCID: https://orcid.org/0000-0001-8462-7000)
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2024-08-16
- DOI
- https://doi.org/10.5599/admet.2403
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00