Beneficial effects of <scp>MGL</scp>‐3196 and <scp>BAM15</scp> combination in a mouse model of fatty liver disease
MGL + BAM15 treatment had overall better efficacy to improve metabolic outcomes in mice fed GAN diet than either monotherapy alone. These data warrant further investigation into combination therapies of THR-β agonists and mitochondrial uncouplers for the potential treatment of disorders related to fatty liver, obesity, and insulin resistance.
Authors
- Kyle L. Hoehn (ORCID: https://orcid.org/0000-0002-0214-3238)
- Frances L. Byrne (ORCID: https://orcid.org/0000-0002-8897-8438)
- Mingyan Zhou (ORCID: https://orcid.org/0000-0002-9210-4151)
- Nicholas Shackel (ORCID: https://orcid.org/0000-0002-1751-1400)
- Webster L. Santos (ORCID: https://orcid.org/0000-0002-4731-8548)
- Ellen M. Olzomer (ORCID: https://orcid.org/0000-0002-5823-0736)
- Lindsay E. Wu (ORCID: https://orcid.org/0000-0002-1599-7574)
- Adam Hargreaves (ORCID: https://orcid.org/0000-0003-0772-7627)
- Calum S Vancuylenburg
- Catherine Li (ORCID: https://orcid.org/0000-0002-1579-649X)
Institutions
- Launceston General Hospital (AU)
- UNSW Sydney (AU)
- Virginia Tech (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1111/apha.14217
- Citations
- 8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Cancer Institute NSW
- University of New South Wales
- National Institutes of Health
- National Health and Medical Research Council