Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing
Reduced insulin and IGF-1 receptor expression have both common and synergistic effects upon elements of healthy mammalian ageing, suggesting future ageing studies should consider targeting both insulin and IGF-1 signalling.
Authors
- Andrew MN Walker (ORCID: https://orcid.org/0000-0003-0380-7283)
- Mark T. Kearney (ORCID: https://orcid.org/0000-0002-9376-8814)
- Marcella Conning-Rowland (ORCID: https://orcid.org/0000-0002-2660-7594)
- Nadira Yuldasheva (ORCID: https://orcid.org/0000-0001-6213-6358)
- Chew W. Cheng
- Stephen Bentley Wheatcroft (ORCID: https://orcid.org/0000-0002-6741-9012)
- Katherine Bridge (ORCID: https://orcid.org/0000-0003-0495-9465)
- Natalie J Haywood (ORCID: https://orcid.org/0000-0002-8762-7257)
- Nele Warmke (ORCID: https://orcid.org/0000-0001-8037-2186)
- Anna Skromna (ORCID: https://orcid.org/0000-0002-4937-8675)
- Michael Drozd (ORCID: https://orcid.org/0000-0003-0255-4624)
- Oliver Brown (ORCID: https://orcid.org/0000-0001-7555-476X)
- Richard M. Cubbon (ORCID: https://orcid.org/0000-0001-7844-3600)
- Cheukyau Luk (ORCID: https://orcid.org/0000-0002-6828-5423)
- Sanjush Dalmia (ORCID: https://orcid.org/0000-0003-0261-2951)
- Nicole T. Watt (ORCID: https://orcid.org/0000-0002-7429-7367)
- N Makava
Institutions
- University of Leeds (GB)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36457
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Academy of Medical Sciences