Hedgehog/Gli2 signaling triggers cell proliferation and metastasis via EMT and wnt/β-catenin pathways in oral squamous cell carcinoma
The Hedgehog/Gli2 pathway induces EMT and activates Wnt/β-catenin pathway to trigger the malignant proliferation and metastasis of OSCC cells, and Gli2 plays a key role in this process, which suggests that targeting Gli2 may be a promising therapeutic strategy for inhibiting the proliferation and metastasis of OSCC.
Authors
- Guohua Song (ORCID: https://orcid.org/0000-0002-0940-1252)
- Yiyan Yang
- Xiaoru Yan
- Jiping Gao (ORCID: https://orcid.org/0000-0002-8968-4423)
- Xuemin Wang (ORCID: https://orcid.org/0000-0002-6251-6745)
- Xiaona Song
- Guoqiang Xu (ORCID: https://orcid.org/0009-0000-1661-2659)
- Junting Yang (ORCID: https://orcid.org/0009-0003-1264-4663)
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36516
- Citations
- 5
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.17