Disseminated juvenile xanthogranuloma harbouring a <i>GAB2::BRAF</i> fusion successfully treated with trametinib: a case report
We present an interesting case of disseminated juvenile xanthogranuloma harbouring a GAB2::BRAF fusion that exhibited dramatic response to trametinib, highlighting the utility of RNA sequencing and targeted next-generation sequencing in non-Langerhans cell histiocytosis in identifying potential therapeutic targets.
Authors
- Xinxin Cao (ORCID: https://orcid.org/0000-0001-7884-3073)
- He Lin
- Kaini Shen (ORCID: https://orcid.org/0000-0003-2381-339X)
- Long Chang (ORCID: https://orcid.org/0000-0002-1026-016X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1093/bjd/ljae328
- Citations
- 2
- Primary Topic
- Histiocytic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65