Metabolic Dysfunction-Associated Fatty Liver Disease and Fibrosis Status in Patients with Type 2 Diabetes Treated at Internal Medicine Clinics: Türkiye DAHUDER Awareness of Fatty Liver Disease (TR-DAFLD) Study
This awareness study aimed to determine the ultrasound (US) examination rates in relation to US-confirmed metabolic dysfunction-associated fatty liver disease (MAFLD) diagnosis in internal medicine outpatients with type 2 diabetes (T2D) across Türkiye. A total of 6283 T2D patients were included in this multicenter retrospective cohort study conducted at 17 internal medicine clinics across Türkiye. The presence and indications for US performed within the last 3 years were recorded along with US-confirmed MAFLD rates, laboratory findings on the day of US, and referral rates. Fibrosis-4 (FIB-4) index was calculated to estimate the risk of advanced liver fibrosis (FIB-4 index ≥ 1.3). Overall, 1731 (27.6%) of 6283 patients had US examination, which revealed MAFLD diagnosis in 69.9% of cases. In addition, 24.4% of patients with US-confirmed MAFLD were at risk of advanced fibrosis (FIB-4 index ≥ 1.3), and the referral rate was 15.5%. In conclusion, our findings emphasize an insufficient MAFLD awareness among clinicians and the likelihood of most of T2D patients to be at risk of living with an unknown status regarding their MAFLD and advanced fibrosis risk.
Authors
- Hilmi Erdem Sümbül (ORCID: https://orcid.org/0000-0002-7192-0280)
- Seher Kır (ORCID: https://orcid.org/0000-0003-2835-1745)
- Hasan Sözel (ORCID: https://orcid.org/0000-0002-9439-1588)
- Ayhan Hilmi Çekın (ORCID: https://orcid.org/0000-0001-7464-8297)
- Banu Açmaz
- Nizameddin Koca (ORCID: https://orcid.org/0000-0003-1457-4366)
- İsmail Demir (ORCID: https://orcid.org/0000-0001-7787-1443)
- İhsan Solmaz (ORCID: https://orcid.org/0000-0002-6624-8063)
- Teslime Ayaz (ORCID: https://orcid.org/0000-0002-3468-1428)
- Eşref Araç (ORCID: https://orcid.org/0000-0001-6041-3817)
- Havva Keskin (ORCID: https://orcid.org/0000-0003-1794-4473)
- Alihan Oral (ORCID: https://orcid.org/0000-0003-1160-9340)
- Gökhan Köker (ORCID: https://orcid.org/0000-0003-1745-8002)
- Hacer Şen (ORCID: https://orcid.org/0000-0002-9290-6285)
- Fatih Necip Arıcı (ORCID: https://orcid.org/0000-0002-1160-2125)
- Sıbel Ocak Serın (ORCID: https://orcid.org/0000-0002-3830-9527)
- Seyit Uyar (ORCID: https://orcid.org/0000-0002-2435-8248)
- Ali Kırık (ORCID: https://orcid.org/0000-0002-7982-9262)
- Yasin Şahintürk
- Hamit Yıldız (ORCID: https://orcid.org/0000-0001-7858-5123)
- Attila Önmez (ORCID: https://orcid.org/0000-0002-7188-7388)
- Mustafa Kanat
- Selçuk Yaylacı
- Şükriye Taşçı
Institutions
- Sakarya University (TR)
- Dicle University (TR)
- Izmir University (TR)
- Ankara University (TR)
- University of Turku (FI)
- Karadeniz Technical University (TR)
- University of Health Science (KH)
- Bursa Technical University (TR)
- Akdeniz University (TR)
- Ondokuz Mayıs University (TR)
- Universidad de Cádiz (ES)
- Biruni University (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Kayseri Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi (TR)
- Izmir Bozyaka Eğitim ve Araştırma Hastanesi (TR)
- S.B.Ü. Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi (TR)
- Düzce Üniversitesi (TR)
- Istanbul Medeniyet University (TR)
- Gaziantep University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- The Turkish Journal of Gastroenterology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.5152/tjg.2024.24045
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55