Use of Metagenomic Next-Generation Sequencing to Identify Pathogens Involved in Central Nervous System Infections
Routine microbiologic testing frequently falls short of detecting all neuroinvasive pathogens. Our research suggests that mNGS offers an alternative means of detecting nosocomial CNS infections. By applying mNGS to CSF samples from patients with meningitis or encephalitis, we were able to improve the ability to diagnose nosocomial neurologic infections.
Authors
- Wei Wu (ORCID: https://orcid.org/0000-0002-1092-603X)
- Jingdi Chen (ORCID: https://orcid.org/0000-0001-7440-4743)
- Liying Zhan (ORCID: https://orcid.org/0000-0001-7580-5696)
- Yaqi Sun
- Raojuan Huang
- Zhihua Lv
- Lu Wang (ORCID: https://orcid.org/0009-0005-5858-8112)
- Yunjing Zhang
Institutions
- Wuhan University (CN)
- 302 Military Hospital of China (CN)
- Wuhan Business University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/idr.s474410
- Citations
- 6
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province