Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming
We have discovered a mechanism in which lipid biosynthesis is controlled by ZDHHC6 and includes the signaling of PPARγ-ACLY in the advancement of CRC. This finding provides a justification for targeting lipid synthesis by blocking ZDHHC6 as a potential therapeutic approach.
Authors
- Qin Kuang (ORCID: https://orcid.org/0000-0002-4111-291X)
- Yan Sun (ORCID: https://orcid.org/0000-0002-8339-7116)
- Junqi Shan (ORCID: https://orcid.org/0000-0002-4273-0808)
- Yao Yao (ORCID: https://orcid.org/0000-0003-3068-766X)
- Xinyu Li (ORCID: https://orcid.org/0000-0001-7175-7332)
- Xianling Dai
- Runqi Sun
- Yanlai Sun
Institutions
- Chongqing University (CN)
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1186/s13046-024-03154-0
- Citations
- 25
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.13
Funders
- National Science Foundation