A Pressure‐Sensitive, Repositionable Bioadhesive for Instant, Atraumatic Surgical Application on Internal Organs
Pressure-sensitive adhesives are widely utilized due to their instant and reversible adhesion to various dry substrates. Though offering intuitive and robust attachment of medical devices on skin, currently available clinical pressure-sensitive adhesives do not attach to internal organs, mainly due to the presence of interfacial water on the tissue surface that acts as a barrier to adhesion. In this work, a pressure-sensitive, repositionable bioadhesive (PSB) that adheres to internal organs by synergistically combining the characteristic viscoelastic properties of pressure-sensitive adhesives and the interfacial behavior of hydrogel bioadhesives, is introduced. Composed of a viscoelastic copolymer, the PSB absorbs interfacial water to enable instant adhesion on wet internal organs, such as the heart and lungs, and removal after use without causing any tissue damage. The PSB's capabilities in diverse on-demand surgical and analytical scenarios including tissue stabilization of soft organs and the integration of bioelectronic devices in rat and porcine models, are demonstrated.
Authors
- Dong Geun Kim (ORCID: https://orcid.org/0009-0005-6996-0477)
- Jooyeun Chong (ORCID: https://orcid.org/0000-0003-0260-1048)
- Yeji Kim (ORCID: https://orcid.org/0000-0002-5423-5994)
- Yung Hsiang Lu
- Christian Paniccia
- Jeffrey M. Karp (ORCID: https://orcid.org/0000-0002-4752-7374)
- Kiwook Hwang
- Kum Seok Nam (ORCID: https://orcid.org/0000-0002-4281-0875)
- Hyunwoo Yuk
- Haeseung Lee (ORCID: https://orcid.org/0000-0002-9947-4032)
- Jiheong Kang (ORCID: https://orcid.org/0000-0003-4446-5494)
- Sanha Kim (ORCID: https://orcid.org/0000-0002-3548-6173)
- Jooik Jeon (ORCID: https://orcid.org/0000-0001-5781-7706)
- Geonho Park (ORCID: https://orcid.org/0000-0002-1976-4460)
- Yuhan Lee
- Congqi Yang
- Jung Keun Hyun (ORCID: https://orcid.org/0000-0001-9254-4424)
- Minyoung Kim (ORCID: https://orcid.org/0000-0002-5078-7142)
- Seongjun Park (ORCID: https://orcid.org/0000-0002-1981-9628)
- Seung Won Oh (ORCID: https://orcid.org/0000-0001-5366-4386)
- Jeong-Won Choi (ORCID: https://orcid.org/0000-0001-8287-450X)
- Jae‐Wook Rhyu
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Korea Advanced Institute of Science and Technology (KR)
- University of California San Diego (US)
- Dankook University (KR)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/adma.202407116
- Citations
- 16
- Primary Topic
- Surgical Sutures and Adhesives
- Type
- article
- Field-Weighted Citation Impact
- 9.16
Funders
- National Research Foundation
- National Research Foundation of Korea
- Korea Advanced Institute of Science and Technology
- Ministry of Science and ICT, South Korea