Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids
We demonstrated a new potential mechanism by which anti-ferroptosis inhibits the progression of keloid fibrosis and identified an ADSC-Exo-based keloid therapeutic strategy. Resisting the occurrence of ferroptosis and the existence of the SLC7A11-GPX4 signaling pathway might serve as a target for ADSC-Exos.
Authors
- Yuan Tian (ORCID: https://orcid.org/0000-0002-3652-2375)
- Jian Yuan
- Zhiyong Diao (ORCID: https://orcid.org/0000-0003-4727-2372)
- Meijia Li (ORCID: https://orcid.org/0009-0003-6495-2748)
- Lijun Hao (ORCID: https://orcid.org/0000-0002-4707-693X)
- Zhishan Xu (ORCID: https://orcid.org/0009-0000-5519-9481)
- Xinyue Chen (ORCID: https://orcid.org/0000-0003-3212-2398)
- Cheng Rong (ORCID: https://orcid.org/0009-0000-6875-4990)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fphar.2024.1431846
- Citations
- 6
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.44