Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region

We illustrated a rare case of malignant solitary fibrous tumor (MSFT) with epithelioid morphology in the occipital region of a 59-year-old female, in which a rare NAB2ex7-STAT6 exon15/16 double fusion subtype was detected by the Next-generation sequencing (NGS) and STAT6 immunohistochemistry (IHC) was diffusely and strongly positively expressed, without recurrence after 20 months of postoperative follow-up. The morphological and molecular genetic aspects and the differential diagnosis are described, and the relevant literature was assessed in order to broaden our understanding and diagnostic capability of this malignancy.

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Publication Details

Journal
Frontiers in Oncology
Published
2024-08-16
DOI
https://doi.org/10.3389/fonc.2024.1339582
Primary Topic
Soft tissue tumor case studies
Type
article
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article

Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region

Xian-bin Tang, Senyuan Luo, Yugang Huang, Ke Huang et al.
Frontiers in Oncology
Soft tissue tumor case studies
article

Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region

Xian-bin Tang, Senyuan Luo, Yugang Huang, Ke Huang, Wenwen Liu, Lingling Yuan, Xiu-wen Chen, Yin-hua Hao
article en

Abstract

We illustrated a rare case of malignant solitary fibrous tumor (MSFT) with epithelioid morphology in the occipital region of a 59-year-old female, in which a rare NAB2ex7-STAT6 exon15/16 double fusion subtype was detected by the Next-generation sequencing (NGS) and STAT6 immunohistochemistry (IHC) was diffusely and strongly positively expressed, without recurrence after 20 months of postoperative follow-up. The morphological and molecular genetic aspects and the differential diagnosis are described, and the relevant literature was assessed in order to broaden our understanding and diagnostic capability of this malignancy.

Frontiers in OncologyVol. 14
Hubei University of Medicine (CN), Taihe Hospital (CN)
Good health and well-being
Openalex Percentile: Top 75%
Soft tissue tumor case studies
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Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region — Xian-bin Tang, Senyuan Luo, et al. · Frontiers in Oncology (2024) | TGRS Research Map | TGRS