Proteomic analysis reveals key differences in pro-stromal corneal tissue between highly myopic males and females
Comparative proteomic analysis of cornea from male and female patients with high myopia revealed increased expression of proteins related to extracellular matrix and collagen I, III, V, and VIII in female patients, and the TGF-β/Smad pathway was an important pathway obtained from the functional analysis, suggesting that extracellular matrix remodeling and collagen fiber synthesis may be more active in the cornea of female patients.
Authors
- Youxin Chen (ORCID: https://orcid.org/0000-0002-7231-5058)
- Ying Li (ORCID: https://orcid.org/0000-0001-7370-1754)
- Di Yu (ORCID: https://orcid.org/0000-0001-6664-2952)
- Shan Yang (ORCID: https://orcid.org/0009-0005-0820-757X)
- Di Chen (ORCID: https://orcid.org/0009-0008-0312-964X)
- Ge Cui
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fmed.2024.1406748
- Citations
- 3
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College