Novel WFS1 variants are associated with different diabetes phenotypes
Our results underscore the importance of early genetic testing for diagnosing young-onset diabetes and highlight the clinical relevance of <i>WFS1</i> variants in increasing ER stress and reducing cell viability. Incorporating these genetic insights into clinical practice can reduce misdiagnoses and improve treatment strategies for related disorders.
Authors
- Zhongyun Zhang (ORCID: https://orcid.org/0009-0004-6737-6966)
- Rulai Han
- Qicheng Ni (ORCID: https://orcid.org/0000-0002-9033-9328)
- Danjie Li
- Weiqing Wang (ORCID: https://orcid.org/0000-0001-6027-3084)
- Yifei Zhang (ORCID: https://orcid.org/0000-0001-8323-1645)
- Jie Hong (ORCID: https://orcid.org/0009-0005-9293-5114)
- Lei Wu (ORCID: https://orcid.org/0000-0001-6309-8891)
- Lei Ye (ORCID: https://orcid.org/0000-0002-5841-2791)
- Guang Ning (ORCID: https://orcid.org/0000-0002-9728-2897)
- Weiqiong Gu (ORCID: https://orcid.org/0000-0003-3029-1016)
- Juan Zhang (ORCID: https://orcid.org/0009-0004-7549-8955)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fgene.2024.1433060
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China