Ovarian carcinosarcomas: p53 status defines two distinct patterns of oncogenesis and outcomes
Most OCSs have a morphologic and molecular profile resembling HGSC; however, some OCSs display a molecular profile that suggests origin through non-serous oncogenic pathways. This molecular distinction has both prognostic and treatment (predictive) implications. These findings underscore the importance of routine p53 IHC testing on all OCS and <i>BRCA1/2</i> testing on p53-mutated OCS.
Authors
- Jennifer Pors (ORCID: https://orcid.org/0000-0002-8675-916X)
- Mary Kinloch (ORCID: https://orcid.org/0000-0002-0092-0312)
- Mark Carey (ORCID: https://orcid.org/0000-0002-0473-6993)
- Basile Tessier‐Cloutier (ORCID: https://orcid.org/0000-0001-8739-3879)
- Dina Bassiouny (ORCID: https://orcid.org/0000-0003-1446-2348)
- Allan Covens (ORCID: https://orcid.org/0000-0001-7958-8502)
- Nelson K.Y. Wong (ORCID: https://orcid.org/0000-0002-7003-6020)
- Martin Köbel (ORCID: https://orcid.org/0000-0002-6615-2037)
- Cheng‐Han Lee (ORCID: https://orcid.org/0000-0003-3283-2007)
- Guangming Han
- Laura Hopkins (ORCID: https://orcid.org/0009-0005-0886-7535)
- Gurdial Dhillon
- Keiyan Sy
- Marta Llaurado-Fernandez
- Kathryn McRae
Institutions
- BC Cancer Agency (CA)
- Sunnybrook Health Science Centre (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Surrey Memorial Hospital (CA)
- McGill University Health Centre (CA)
- Spinal Cord Injury BC (CA)
- University of Saskatchewan (CA)
- Saskatchewan Cancer Agency (CA)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fonc.2024.1408196
- Citations
- 2
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Children's Health Research Institute
- Cancer Research Society
- Women and Children's Health Research Institute
- University of Alberta
- BC Cancer Foundation