Multi-omics analysis reveals the impact of influenza a virus host adaptation on immune signatures in pig tracheal tissue
Central components of the JAK-STAT pathway, apoptosis, pyrimidine metabolism, and the cytoskeleton were significantly altered depending on infection with swine- or human-adapted virus and might be relevant mechanisms in relation to antiviral immunity against putative zoonotic IAV. Based on our findings, we hypothesize that during host adaptation, IAV evolve to modulate important host cell elements to favor viral infectivity and replication.
Authors
- Louise Brogaard (ORCID: https://orcid.org/0000-0003-4571-6822)
- Kerstin Skovgaard (ORCID: https://orcid.org/0000-0001-5663-4879)
- Lars Erik Larsen (ORCID: https://orcid.org/0000-0003-0730-5555)
- Ramona Trebbien (ORCID: https://orcid.org/0000-0003-2352-5726)
- Betina Lyngfeldt Henriksen (ORCID: https://orcid.org/0009-0006-6838-9798)
- Helena Aagaard Glud (ORCID: https://orcid.org/0000-0002-0477-7584)
- Konstantinos Kalogeropoulos (ORCID: https://orcid.org/0000-0003-3907-9281)
- Ulrich auf dem Keller (ORCID: https://orcid.org/0000-0002-3431-7415)
- Charlotte Sonne Kristensen (ORCID: https://orcid.org/0000-0003-2235-809X)
- Cathrine Agnete Larsen (ORCID: https://orcid.org/0000-0001-7623-563X)
- Yaolei Zhang (ORCID: https://orcid.org/0000-0003-2131-0254)
- Chrysillis Hellemann Polhaus
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1432743
- Citations
- 4
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Novo Nordisk
- Novo Nordisk Fonden