Accumulation of branched-chain amino acids deteriorates the neuroinflammatory response of Müller cells in diabetic retinopathy via leucine/Sestrin2-mediated sensing of mTOR signaling
We found that BCAA catabolism is hindered in DR through mTORC1 activation. Leucine plays a key role in inducing mTORC1 by sensing Sestrin2 in Müller cells. Targeting Sestrin2 may ameliorate the toxic effects of BCAA accumulation on Müller cells in DR.
Authors
- X. Allen Li (ORCID: https://orcid.org/0000-0003-2260-0245)
- Qiaoyun Gong (ORCID: https://orcid.org/0000-0002-3307-1695)
- Junwei Fang (ORCID: https://orcid.org/0000-0002-4303-1750)
- Dawei Luo (ORCID: https://orcid.org/0000-0001-7948-4164)
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-0423-6868)
- Yupeng Xu (ORCID: https://orcid.org/0000-0002-4788-7003)
- Hai-Yan Wang (ORCID: https://orcid.org/0000-0002-3770-5253)
- Rulin Zhang (ORCID: https://orcid.org/0000-0003-3402-9090)
- Zihan Yin
Institutions
- Shanghai University (CN)
- University of Shanghai for Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Acta Diabetologica
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1007/s00592-024-02349-3
- Citations
- 9
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China