Bioinformatic analysis of hippocampal histopathology in Alzheimer’s disease and the therapeutic effects of active components of traditional Chinese medicine
Mitochondrial to synaptic vesicle dysfunction pathways were enriched in downregulated genes. Despite downregulation, UBB and SNCA proteins accumulate in AD brains. TCM studies suggest curcumin and echinacoside may improve hippocampal pathology and cognitive impairment in AD. Further investigation into their mechanisms is needed.
Authors
- Min Zhan (ORCID: https://orcid.org/0000-0002-6650-0337)
- Sun Linjuan
- Huan Wang (ORCID: https://orcid.org/0000-0001-7987-3039)
- Yutong Li (ORCID: https://orcid.org/0000-0003-1619-9803)
- Chunying He
- Zhiyan Chen (ORCID: https://orcid.org/0000-0002-0192-418X)
- Xiaohua Hu (ORCID: https://orcid.org/0000-0002-2161-1324)
- Du Yida
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fphar.2024.1424803
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- National Natural Science Foundation of China