Bactericidal, anti-hemolytic, and anticancerous activities of phytofabricated silver nanoparticles of glycine max seeds

Our results showed that the synthesized GM-AgNPs were spiral-shaped with a size range of 5-50 nm. The antibacterial activity against <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> showed the maximum zone of inhibition at 250 μg/mL in comparison with gentamicin. On exploring the anti-hemolysis efficiency, at 200 μg/mL, GM-AgNPs showed no hemolysis in comparison to the extract which showed 40% hemolysis. On analysis of GM-AgNPs against the breast cancer cell line, the nanoparticles displayed the IC50 value of 74.04 μg/mL. Furthermore, at the IC50 concentration, cancer cell migration was reduced. The mechanism of action of GM-AgNPs confirmed the initiation of apoptosis and cell cycle arrest in the sub-G0/G1 (growth phase) phase by 48.19%. In gene expression and protein expression analyses, Bax and Bcl-2 were altered to those of normal physiology.

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Publication Details

Journal
Frontiers in Chemistry
Published
2024-08-16
DOI
https://doi.org/10.3389/fchem.2024.1427797
Citations
9
Primary Topic
Nanoparticles: synthesis and applications
Type
article
Field-Weighted Citation Impact
1.05

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article

Bactericidal, anti-hemolytic, and anticancerous activities of phytofabricated silver nanoparticles of glycine max seeds

K. C. Prakasha, Bhargav Shreevatsa, Chandan Shivamallu, C.M. Hemanth Kumar et al.
9 citations
Frontiers in Chemistry
Nanoparticles: synthesis and applications
1.05
article

Bactericidal, anti-hemolytic, and anticancerous activities of phytofabricated silver nanoparticles of glycine max seeds

K. C. Prakasha, Bhargav Shreevatsa, Chandan Shivamallu, C.M. Hemanth Kumar, Shiva Prasad Kollur, Prasanna D. Shivaramu, Tanveer A. Wani, Kavitha Raj Varadaraju, H. R. Prakruthi, B. M. Chandra Shekara, K. B. Vijendra Kumar
article en
9 citations

Abstract

Our results showed that the synthesized GM-AgNPs were spiral-shaped with a size range of 5-50 nm. The antibacterial activity against <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i> showed the maximum zone of inhibition at 250 μg/mL in comparison with gentamicin. On exploring the anti-hemolysis efficiency, at 200 μg/mL, GM-AgNPs showed no hemolysis in comparison to the extract which showed 40% hemolysis. On analysis of GM-AgNPs against the breast cancer cell line, the nanoparticles displayed the IC50 value of 74.04 μg/mL. Furthermore, at the IC50 concentration, cancer cell migration was reduced. The mechanism of action of GM-AgNPs confirmed the initiation of apoptosis and cell cycle arrest in the sub-G0/G1 (growth phase) phase by 48.19%. In gene expression and protein expression analyses, Bax and Bcl-2 were altered to those of normal physiology.

Frontiers in ChemistryVol. 12
JSS Academy of Higher Education and Research (IN), International Institute of Information Technology Bangalore (IN), King Saud University (SA), Hi Tech BioSciences India (India) (IN), Visvesvaraya Technological University (IN), Amrita Vishwa Vidyapeetham (IN)
Amrita Vishwa Vidyapeetham University, JSS Academy of Higher Education and Research, King Saud University
Zero hunger
Openalex Percentile: Top 21%
Nanoparticles: synthesis and applications
1.05
DOIOpen Access PDFOpenAlex
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