Rh(I)/Sulfoxide‐Imine‐Olefin Complex Catalyzed Enantioselective Allylic Alkylation of 2‐Fluoromalonate: Synthesis of Chiral α‐Fluorolactone Bearing Vicinal Stereogenic Centers
Highly enantioselective Rh-catalyzed allylic substitution of the racemic branched allylic substrates with 2-fluoromalonate was realized enabled by a novel chiral sulfoxide-imine-olefin ligand under mild reaction conditions. The utilization of CuSO<sub>4</sub> is beneficial for improving the enantioselectivity. Notably, the chiral fluoro-containing allyl products can be employed in a selective cyclic esterification to form chiral α-fluorolactone bearing vicinal stereogenic centers.
Authors
- Hongbo Zhang (ORCID: https://orcid.org/0000-0002-3866-7711)
- Haibin Jiang (ORCID: https://orcid.org/0009-0004-6844-107X)
- Wenwen Zhao (ORCID: https://orcid.org/0000-0002-7457-4977)
- Sheng‐Cai Zheng (ORCID: https://orcid.org/0000-0001-5201-7785)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0003-4293-7523)
- Xiao-Ming Zhao
Institutions
- Tongji University (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1002/chem.202402875
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.16
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities