Novel therapeutic targets for primary open-angle glaucoma identified through multicenter proteome-wide mendelian randomization
Our integrated study identified eight potential associated proteins for POAG. These proteins play important roles in neuroprotection, extracellular matrix regulation and oxidative stress. Therefore, they have promising potential as therapeutic targets to combat POAG.
Authors
- Shangshang Gao (ORCID: https://orcid.org/0009-0006-3565-8816)
- Weichen Yuan
- Fangkun Zhao
- Wei Sun (ORCID: https://orcid.org/0000-0003-1416-3313)
- Jun Li (ORCID: https://orcid.org/0009-0002-4497-9305)
Institutions
- Fourth Affiliated Hospital of China Medical University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/fphar.2024.1428472
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.08