Comparison of measles plaque reduction neutralization test (PRNT) and measles virus-specific IgG ELISA for assessment of immunogenicity of measles-mumps-rubella vaccination at 5–7 months of age and maternal measles antibodies
The correlation between measles IgG and PRNT antibodies was low. Seroprotection was underestimated using ELISA. High-accuracy tests are needed to avoid misclassifications and practices that lead to primary or secondary vaccine failure or retention of vaccination in outbreak settings. Baseline PPV and NPV suggested some applicability of ELISA in predicting serological protection in this age group. However, PRNT may be the only accurate estimator of serological protection in young infants.
Authors
- Jesper Kiehn Sørensen (ORCID: https://orcid.org/0000-0001-7735-4622)
- Jannet Svensson (ORCID: https://orcid.org/0000-0002-9365-0728)
- Michelle Malon (ORCID: https://orcid.org/0000-0002-2436-4293)
- Lone Graff Stensballe (ORCID: https://orcid.org/0000-0003-1569-153X)
- Andreas Jensen (ORCID: https://orcid.org/0000-0003-4302-2982)
- Dorthe Maria Vittrup
- Anne Cathrine Zimakoff (ORCID: https://orcid.org/0000-0001-9872-6608)
- Eric A. F. Simões (ORCID: https://orcid.org/0000-0001-5588-2723)
- Brickley Littell
Institutions
- University of Copenhagen (DK)
- Statistics Denmark (DK)
- Herlev Hospital (DK)
- Rigshospitalet (DK)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Vaccine X
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1016/j.jvacx.2024.100548
- Citations
- 3
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Innovationsfonden