Distinct protein patterns related to postnatal development in small for gestational age preterm infants
Postnatal changes of circulating proteins in preterm infants have not fully been elucidated but may contribute to development of health complications. Mass spectrometry-based analysis is an attractive approach to study circulating proteins in preterm infants with limited material. Longitudinal plasma profiling reveals postnatal developmental-related patterns in preterm infants (314/833 proteins) including previously described changes, but also previously unreported proteins. Longitudinal monitoring revealed an immune response signature between SGA and AGA infants. This study highlights the importance of taking postnatal changes into account for translational studies in preterm infants.
Authors
- Arie J. Hoogendijk (ORCID: https://orcid.org/0000-0002-3082-2289)
- Suzanne Fustolo‐Gunnink
- Hilde van der Staaij (ORCID: https://orcid.org/0000-0003-1361-7002)
- Carmen van der Zwaan
- Joost Rotteveel (ORCID: https://orcid.org/0000-0001-7635-564X)
- Martijn J.J. Finken (ORCID: https://orcid.org/0000-0002-6589-9788)
- Michelle Romijn (ORCID: https://orcid.org/0000-0003-3558-554X)
- Maartje van den Biggelaar (ORCID: https://orcid.org/0000-0001-6970-5496)
- Wes Onland (ORCID: https://orcid.org/0000-0002-9623-0606)
- Anton H. van Kaam (ORCID: https://orcid.org/0000-0003-4030-7085)
- Eva R. Smit (ORCID: https://orcid.org/0009-0008-2001-1205)
- Pieter Langerhorst
Institutions
- Leiden University Medical Center (NL)
- Sanquin (NL)
- Emma Kinderziekenhuis (NL)
- Willem-Alexander Kinderziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1038/s41390-024-03481-0
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Landsteiner Foundation for Blood Transfusion Research