Rapid Access to Triarylmethanes (TRAMs) Enabled by Direct Electrolysis of Indolizines with Carbonyls
A fast, scalable, transition metal-free, electrochemical sp<sup>2</sup> geminal functionalization of carbonyls enabled by anodic oxidation of non-prefunctionalized chromone-fused indolizines to access the triarylmethanes (TRAMs) is disclosed for the first time. This momentary electrochemical approach features the use of readily available carbonyls, implantation of the C(sp<sup>3</sup>) center (well-known for dramatically improving biological active potency), a broad substrate scope, and excellent yields of TRAMs with fluorescence properties.
Authors
- Pooja Kumari Jat
- Satpal Singh Badsara (ORCID: https://orcid.org/0000-0002-9839-5113)
Institutions
- University of Rajasthan (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1021/acs.joc.4c01198
- Citations
- 3
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board