Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover
Our findings confirm that passively administered fluoxetine reaches the infant brain in the form of norfluoxetine and may manipulate processes of oxidative stress regulation. Further studies into the long-term bio-behavioural effects are however needed to effectively inform breast feeding mothers on the safety of antidepressant-use.
Authors
- Malie Rheeders (ORCID: https://orcid.org/0000-0001-7222-2663)
- Stephan F. Steyn (ORCID: https://orcid.org/0000-0002-0023-9711)
- Francois P. Viljoen (ORCID: https://orcid.org/0000-0002-0145-7104)
- Linda Brand
Institutions
- North-West University (ZA)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1186/s40360-024-00775-1
- Citations
- 1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- North-West University