3056 Everything is connected to everything else

enhancement, was found asymmetrically involving the lumbosacral plexus.Extensive investigation, including CSF analysis, identified no alternate aetiology.Symptoms resolved with analgesia and drug cessation.No recurrence occurred with rechallenge with dose reduction and concurrent high dose B12 and folate supplementation.To our knowledge no case of MAT2A inhibitor associated neuropathy has been described in the literature.As novel anticancer therapies are discovered it remains important to ensure that potential toxicities, and their mechanisms, are understood to enable clinicians to identify ways of mitigating and treating these while maintaining anti-tumour effects.