3166 Spontaneous intracranial hypotension (SIH) during late pregnancy

Conclusion Due to the depletion of peripheral CD4 + and CD8 + T cells and initially of CD 19+ B cells, an increased risk of skin tumours after alemtuzumab is plausible.Our case report & review summarizes the mechanisms based on multiple case reports and series, highlights the need for registry data for such side-effects in large populations of MS who received alemtuzumab and emphasizes the need for multidisciplinary involvement in MS care.