Metabolomic comparison of postprandial distress syndrome patients with and without duodenal eosinophilia
In patients with dyspepsia and early satiety, duodenal mucosal eosinophilia is associated with metabolites levels which are consistent with increased oxidative stress and alterations in lipid metabolism. Eosinophilia was also associated with lower carnitine levels. These alterations may contribute to pathophysiology and represent therapeutic targets.
Authors
- Jennifer M. Colombo (ORCID: https://orcid.org/0000-0002-0550-8255)
- Meenal Singh
- Jennifer V. Schurman (ORCID: https://orcid.org/0000-0002-5331-8069)
- Deepa Ajit (ORCID: https://orcid.org/0000-0002-6062-7070)
- Valentina Shakhnovich (ORCID: https://orcid.org/0000-0003-3744-648X)
- Chance S. Friesen
- Stuti Dalal
Institutions
- Children's Mercy Hospital (US)
- Ironwood Pharmaceuticals (United States) (US)
- Metabolon (United States) (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1002/jpn3.12351
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 1.15