Development of accurate detection methods for hotspot mutations in non-small cell lung carcinoma

Non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) are two major types of lung cancer and are responsible for the highest mortality rates. The rate of NSCLC is approximately 80% to 85% of lung cancers. Hotspots in cancer can be defined as sites in DNA and proteins that are more likely to be mutated. Hotspot mutations are also related to the treatment of the corresponding cancer as the development of targeted agents acts as a major driving force. In this paper, the comprehensive synthesis of results is shown from studies on hotspot mutations in NSCLC. The findings indicate the specific location of the hotspot mutation with the corresponding sequencing method in diagnostic yield and several treatments.