Profiles and interactions of gut microbiome and intestinal microRNAs in pediatric Crohn’s disease
Since previous studies have focused on the change of the fecal gut microbiome and intestinal tissue miRNA in pediatric Crohn's disease (CD), the relationship between them in different stages is still not clear. This is the first study to explore the gut microbiota and miRNA and their correlations with the Pediatric Crohn's Disease Activity Index (PCDAI). Crohn's Disease Endoscopic Index of Severity (CDEIS), and calprotectin, by applying two omics approach in three different groups (active CD, CD in remission with exclusive enteral nutrition or infliximab induction therapy, and the healthy controls). Both gut microbiome structure and the miRNA profiles were significantly changed in the different stage of CD. Seven key gut microbiome at species and eight key miRNAs were found, and their close interactions were further fully investigated by miRNA target prediction.
Authors
- Youyou Luo (ORCID: https://orcid.org/0000-0002-0185-1371)
- Jingan Lou (ORCID: https://orcid.org/0000-0001-9142-5378)
- Ana Liu
- Jindan Yu (ORCID: https://orcid.org/0000-0002-3390-1660)
- Yan Ni (ORCID: https://orcid.org/0000-0003-1779-7266)
- Gan Yang
- Qi Cheng (ORCID: https://orcid.org/0000-0001-6026-8162)
- Yao Lv (ORCID: https://orcid.org/0000-0001-9434-9665)
- Youhong Fang (ORCID: https://orcid.org/0000-0003-3686-1016)
- Yue Lou (ORCID: https://orcid.org/0000-0003-4997-2962)
- Cuifang Xu (ORCID: https://orcid.org/0009-0009-8616-2791)
- Jie Chen (ORCID: https://orcid.org/0000-0002-5929-7262)
- Yu Yu (ORCID: https://orcid.org/0000-0002-0209-0586)
- Hong Zhao (ORCID: https://orcid.org/0000-0001-8991-7824)
- Kerong Peng (ORCID: https://orcid.org/0000-0001-6321-5672)
- Changjun Zhen
- Yudie Hu
Institutions
- Children's Hospital of Zhejiang University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1128/msystems.00783-24
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province