Morphographic Changes in the Electrocardiogram of Colossoma macropomum Caused by Exposure to Manganese
Manganese (Mn<sup>2+</sup>) is an abundant chemical element in the earth's crust and is present in soil, water, and industrial environments, including mining, welding, and battery manufacturing. Manganese (Mn) is an essential metal needed as a cofactor for many enzymes to maintain proper biological functions. Excessive exposure to Mn in high doses can result in a condition known as manganism, which results in disorders of the neurological, cardiac, and pulmonary systems. The aim of this study was to assess cardiac susceptibility to manganese intoxication in <i>Colossoma macropomum</i> subjected to a fixed concentration of 4 mg/mL for a period of up to 96 h. This study used 45 Tambaquis (30.38 ± 3.5 g) divided into five groups of 9 animals/treatment. The treated groups were exposed to the manganese concentration for a period of 24, 48, 72, and 96 h, after which the animals' ECGs were recorded, showing heart rate, R-R interval, P-Q interval, QRS complex duration and S-T interval. The results showed that cardiac activity decreased as the contact time increased, with an increase in the P-Q and S-T intervals. This indicates that the breakdown of circulatory homeostasis in these animals was caused by contact time with manganese.
Authors
- Clarissa Araújo da Paz (ORCID: https://orcid.org/0000-0002-3804-0951)
- Tárcio dos Santos Cabral (ORCID: https://orcid.org/0000-0001-6534-7900)
- Moisés Hamoy (ORCID: https://orcid.org/0000-0002-2931-4324)
- Lorena Meirelis do Nascimento (ORCID: https://orcid.org/0000-0002-9704-1102)
- Luciana Eiró‐Quirino (ORCID: https://orcid.org/0000-0002-8771-9784)
- Daniella Bastos de Araújo (ORCID: https://orcid.org/0000-0002-4281-2619)
- Nilton Akio Muto (ORCID: https://orcid.org/0000-0001-6125-5558)
- Maria Adrina Paixão de Souza da Silva (ORCID: https://orcid.org/0000-0002-7202-4541)
- Anara de Sousa Barbosa (ORCID: https://orcid.org/0009-0004-8404-1834)
- Anthony Lucas Gurgel do Amaral (ORCID: https://orcid.org/0000-0002-7380-059X)
- Yris da Silva Deiga (ORCID: https://orcid.org/0009-0005-5974-3591)
- Murilo Farias dos Santos (ORCID: https://orcid.org/0000-0002-3594-5915)
- Maria Klara Otake Hamoy
- Rodrigo Gonçalves dos Santos
- Luana Vasconcelos de Souza (ORCID: https://orcid.org/0009-0008-4609-0327)
- Tays Mata Câmara (ORCID: https://orcid.org/0009-0009-8443-217X)
- Rayllan da Cunha Ferreira (ORCID: https://orcid.org/0009-0004-8733-9759)
Institutions
- Amazon (United States) (US)
- Character (US)
- Materials Processing (United States) (US)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3390/ijms25168910
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.21