NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors
NR4A factors regulate CAR-T cell persistence and stemness through mitochondrial gene expression, therefore NR4A is a highly promising target for the generation of superior CAR-T cells against solid tumors.
Authors
- Minako Ito (ORCID: https://orcid.org/0000-0002-5809-472X)
- Akihiko Yoshimura (ORCID: https://orcid.org/0000-0001-5676-8949)
- Taeko Hayakawa (ORCID: https://orcid.org/0000-0001-8539-8051)
- Makoto Ando (ORCID: https://orcid.org/0000-0003-1836-8885)
- Tanakorn Srirat
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Kensuke Nakagawara (ORCID: https://orcid.org/0000-0001-5249-6923)
- Setsuko Mise‐Omata (ORCID: https://orcid.org/0000-0001-6371-9280)
Institutions
- Kyushu University (JP)
- Tokyo University of Science (JP)
- Keio University (JP)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/jitc-2023-008665
- Citations
- 29
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 8.19
Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Japan Agency for Medical Research and Development
- Keio University
- Yasuda Memorial Medical Foundation
- Princess Takamatsu Cancer Research Fund
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology
- Moonshot Research and Development Program