Germline RAD51C and RAD51D Mutations in High-Risk Chinese Breast and/or Ovarian Cancer Patients and Families
Taking the family studies in our registry and tumor molecular pathology together, we concluded that this relatively common RAD51D variant showed incomplete penetrance in our local Chinese community. Personalized genetic counseling emphasizing family history for families with this variant, as suggested at the UK Cancer Genetics Group (UKCGG) Consensus meeting, would also be appropriate in Chinese families.
Authors
- Cecilia Y.S. Ho
- Ava Kwong (ORCID: https://orcid.org/0000-0002-6968-9489)
- Sze Keong Tey (ORCID: https://orcid.org/0000-0002-2421-9053)
- Chun Hang Au (ORCID: https://orcid.org/0000-0002-1707-0991)
- Edmond S.K. (ORCID: https://orcid.org/0000-0002-1259-2205)
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Sanatorium and Hospital (HK)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Personalized Medicine
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3390/jpm14080866
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- University of Hong Kong
- Health and Medical Research Fund