3178 Overlapping clinical phenotype of neurodegenerative disorders from TBK1 mutation

any suicidality, fatal and non-fatal; suicidal ideation; and suicidal behaviour.Results Database searches yielded 842 citations, with 761 articles excluded after title and abstract screening.A total of 20 citations underwent evaluation, leading to the exclusion of 10 non-eligible studies during full-text review.Ultimately, 10 studies were deemed eligible for inclusion in the systematic review. Conclusion/DiscussionExisting research underscores a significant association between an elevated risk of suicidal behaviours in both clinical and general populations among chronic migraineurs, with or without aura, worldwide.Future studies are imperative to establish clinical guidelines for risk assessment, targeted interventions, and evidence-based migraine treatment, aiming to mitigate the risk of suicide within this vulnerable population.