The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus
Our findings reveal a GBS strain-specific ability to infect the blood-CSF barrier, which appears to be an important site of bacterial entry and an active site of immune cell trafficking in response to infection.
Authors
- Lionel Costa (ORCID: https://orcid.org/0000-0003-4620-137X)
- Claire Poyart (ORCID: https://orcid.org/0000-0003-2158-6293)
- Asmaa Tazi (ORCID: https://orcid.org/0000-0001-9531-9177)
- Jean‐François Ghersi‐Egea (ORCID: https://orcid.org/0000-0002-0181-4909)
- Nathalie Strazielle
- Julie Guignot (ORCID: https://orcid.org/0000-0001-8890-4028)
- Eva Aznar
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Hôpital Cochin (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- The Enteric Nervous System in Gut and Brain Disorders (FR)
- Institut Cochin (FR)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1186/s12987-024-00564-2
- Citations
- 10
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 5.43
Funders
- Purdue University
- Agence Nationale de la Recherche