Effect of altered production and storage of dopamine on development and behavior in C. elegans
Our results provide additional evidence that the dopamine system impacts the development, growth, and reproduction in <i>C. elegans</i>. Furthermore, our data suggest that endogenously increasing the production of dopamine mitigates deficits in <i>C. elegans</i> lacking the ability to package dopamine into synaptic vesicles. The novel strain, MBIA, and novel analyses of development and reproduction presented here can be utilized in developmental neurotoxicity experiments.
Authors
- Jocelyn Dicent (ORCID: https://orcid.org/0000-0002-5095-2478)
- Meghan L. Bucher (ORCID: https://orcid.org/0000-0001-7613-3836)
- Elizabeth L. Martin (ORCID: https://orcid.org/0000-0002-7796-740X)
- Gary W. Miller (ORCID: https://orcid.org/0000-0001-8984-1284)
- Irene Lee (ORCID: https://orcid.org/0000-0003-0004-6802)
- Charlotte Rose Depew
- Ava C. Knickerbocker
Institutions
- Columbia University (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2024-08-16
- DOI
- https://doi.org/10.3389/ftox.2024.1374866
- Citations
- 3
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Parkinson's Foundation