Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice
This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.
Authors
- Rou-An Chen (ORCID: https://orcid.org/0000-0001-8351-9278)
- Suraphan Panyod (ORCID: https://orcid.org/0000-0001-8998-375X)
- Chi‐Chang Huang (ORCID: https://orcid.org/0000-0003-1446-6787)
- Ting‐Chin David Shen
- Yea-Jing Tseng
- Huai‐Syuan Huang
- Chi‐Tang Ho (ORCID: https://orcid.org/0000-0001-8273-2085)
- Sin-Yi Peng
- Ming‐Shiang Wu (ORCID: https://orcid.org/0000-0002-1940-6428)
- Wei‐Kai Wu (ORCID: https://orcid.org/0000-0002-9476-8998)
- Chun‐Jen Liu (ORCID: https://orcid.org/0000-0002-6202-0993)
- Yi‐Hsun Chen (ORCID: https://orcid.org/0000-0001-9981-5143)
- Lee‐Yan Sheen (ORCID: https://orcid.org/0000-0001-5541-652X)
- Hsiao-Li Chuang (ORCID: https://orcid.org/0000-0002-3718-9076)
- Ya-Chi Hsieh
Institutions
- Rutgers, The State University of New Jersey (US)
- National Taiwan University of Science and Technology (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Laboratoire des Biomolécules (FR)
- National Institutes of Applied Research (TW)
- National Taipei University of Education (TW)
- National Taiwan Sport University (TW)
- University of Pennsylvania (US)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1038/s41387-024-00306-1
- Citations
- 13
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- National Science and Technology Council