On Water: Diastereoselective Synthesis of Functionalized 3‐Nitrodihydroquinolin‐4(1<i>H</i>)‐ones Under Catalyst‐Free Conditions

Abstract Herein we describe an uncatalyzed and eco‐friendly methodology for the diastereoselective synthesis of 3‐nitro dihydroquinolin‐4(1 H )‐ones through an imine formation‐cyclization reaction on water medium. Water is an essential medium to effect this reaction efficiently without any catalyst. In addition, the synthesis of deuterium labelled 3‐nitrodihydroquinolin‐4(1 H )‐ones has been accomplished using this protocol. The key characteristics of this approach include catalyst free, scalable, mild reaction condition, easy isolation, and greenest solvent medium.