Epimedin A inhibits the PI3K/AKT/NF-κB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression
The findings indicated that EA can negatively regulate osteoclastogenesis by inhibiting the TRAF6/PI3K/AKT/NF-κB axis and that ameliorating ovariectomy-induced osteoporosis in rats with EA may be a promising potential therapeutic strategy for the treatment of osteoporosis.
Authors
- Jun Li (ORCID: https://orcid.org/0009-0004-4092-2365)
- Tian Q. Huo
- Cen H. Wu
- Ting Yang (ORCID: https://orcid.org/0009-0007-2681-0094)
- Jia J. Wei
- Cheng J. Wei
- Hong Zhao
- Tao Zou
Institutions
- Nanjing University of Chinese Medicine (CN)
- Yunnan Provincial Hospital of Traditional Chinese Medicine (CN)
- Changzhou No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1186/s10020-024-00893-w
- Citations
- 12
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.81