Transcriptomic Heterogeneity of <i>EGFR</i> -Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Our study demonstrated that most t-SCLC cases showed neuronal subtypes with low EGFR expression. Differentially expressed gene analysis and t-SCLC preclinical models identified an epigenetic modifier as a promising treatment strategy for t-SCLC.
Authors
- Ja‐Lok Ku (ORCID: https://orcid.org/0000-0002-7090-537X)
- Soyeon Kim (ORCID: https://orcid.org/0009-0008-7377-7685)
- Dae Seog Heo (ORCID: https://orcid.org/0000-0001-5221-173X)
- Jaemoon Koh (ORCID: https://orcid.org/0000-0002-2824-5080)
- Yoon Kyung Jeon (ORCID: https://orcid.org/0000-0001-8466-9681)
- Doo Hyun Chung
- Bhumsuk Keam (ORCID: https://orcid.org/0000-0001-8196-4247)
- Jeonghwan Youk (ORCID: https://orcid.org/0000-0002-6761-3958)
- Dong‐Wan Kim (ORCID: https://orcid.org/0000-0001-5124-7132)
- Tae Min Kim (ORCID: https://orcid.org/0000-0001-6145-4426)
- Miso Kim (ORCID: https://orcid.org/0000-0002-4064-4199)
- Songji Oh (ORCID: https://orcid.org/0000-0002-0308-4962)
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0160
- Citations
- 12
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Research Foundation of Korea