The Impact of Li-Fraumeni and Germline Retinoblastoma Mutations on Leiomyosarcoma Initiation, Outcomes, and Genetic Testing Recommendations
Although patients with ULMS had a relatively low proportion of PGV, a high percentage of patients with STLMS with PGV had tumor biallelic status, indicating that PGV drive tumorigenesis in these individuals. These findings have significant implications for genetic testing recommendations.
Authors
- Sarah Chiang (ORCID: https://orcid.org/0000-0001-9698-0936)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Martee L. Hensley (ORCID: https://orcid.org/0009-0004-9956-1306)
- David H. Abramson (ORCID: https://orcid.org/0000-0002-0118-6391)
- Diana L. Mandelker (ORCID: https://orcid.org/0000-0003-4154-0567)
- Sujana Movva (ORCID: https://orcid.org/0000-0002-6569-6606)
- Robert G. Maki (ORCID: https://orcid.org/0000-0002-9853-2528)
- Josephine K. Dermawan (ORCID: https://orcid.org/0000-0002-1139-2914)
- Cristina R. Antonescu (ORCID: https://orcid.org/0000-0002-9717-8205)
Institutions
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1160
- Citations
- 5
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Sarcoma Foundation of America
- Cycle for Survival
- National Cancer Institute