YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities
YAP1 defines distinct subsets of LCNEC with unique biology. These findings highlight the potential for YAP1 to guide personalized treatment strategies for LCNEC.
Authors
- Veronica Y. Novegil
- Azusa Tanimoto (ORCID: https://orcid.org/0000-0002-6643-3867)
- Benjamin B. Morris (ORCID: https://orcid.org/0000-0001-7415-7703)
- Don L. Gibbons (ORCID: https://orcid.org/0000-0003-2362-3094)
- Bernard E. Weissman (ORCID: https://orcid.org/0000-0002-1827-2309)
- Bingnan Zhang (ORCID: https://orcid.org/0000-0002-1821-6243)
- C. Allison Stewart (ORCID: https://orcid.org/0000-0002-7758-1179)
- B. Leticia Rodriguez (ORCID: https://orcid.org/0000-0001-8406-7509)
- Kavya Ramkumar (ORCID: https://orcid.org/0000-0002-5864-2204)
- Alejandra G. Serrano (ORCID: https://orcid.org/0000-0001-6759-9239)
- Pedro Rocha (ORCID: https://orcid.org/0000-0003-3221-7354)
- John Victor Heymach (ORCID: https://orcid.org/0000-0001-9068-8942)
- Carl M. Gay (ORCID: https://orcid.org/0000-0002-4907-0718)
- Robert J. Cardnell (ORCID: https://orcid.org/0009-0005-6203-0234)
- Lauren A. Byers (ORCID: https://orcid.org/0000-0002-0780-2677)
- Samera H. Hamad (ORCID: https://orcid.org/0000-0003-4997-3324)
- Luisa M. Solis Soto (ORCID: https://orcid.org/0000-0002-1253-630X)
- Yan Yang (ORCID: https://orcid.org/0000-0003-0131-7993)
- Yuanxin Xi (ORCID: https://orcid.org/0000-0001-5509-2043)
- Michael Frumovitz (ORCID: https://orcid.org/0000-0002-0810-2648)
- Moushumi Sahu
- Runsheng Wang
- Natalie I. Vokes (ORCID: https://orcid.org/0000-0002-3766-5335)
- Lixia Diao (ORCID: https://orcid.org/0000-0001-6995-4492)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Li Shen (ORCID: https://orcid.org/0000-0001-8427-9448)
- Neda Kalhor (ORCID: https://orcid.org/0000-0001-6891-6435)
- Bonnie S. Glisson
- Alberto Duarte
Institutions
- University of North Carolina at Chapel Hill (US)
- The University of Texas MD Anderson Cancer Center (US)
- Cooper Medical School of Rowan University (US)
- Vall d'Hebron Hospital Universitari (ES)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0361
- Citations
- 12
- Primary Topic
- Bacillus and Francisella bacterial research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- U.S. Department of Defense
- LUNGevity Foundation
- Cancer Prevention and Research Institute of Texas
- Neuroendocrine Tumor Research Foundation
- Rexanna's Foundation
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute