Artificial Intelligence-Powered Spatial Analysis of Tumor-Infiltrating Lymphocytes as a Potential Biomarker for Immune Checkpoint Inhibitors in Patients with Biliary Tract Cancer
AI-IP based on spatial TIL analysis was effective in predicting the efficacy outcomes in patients with BTC treated with anti-PD1 therapy. Further validation is necessary in the context of anti-PD1/L1 plus gemcitabine-cisplatin.
Authors
- Taebum Lee (ORCID: https://orcid.org/0000-0002-9472-0644)
- Inkeun Park (ORCID: https://orcid.org/0000-0003-3064-7895)
- Choong‐kun Lee (ORCID: https://orcid.org/0000-0001-5151-5096)
- Eui‐Cheol Shin (ORCID: https://orcid.org/0000-0002-6308-9503)
- Yoojoo Lim (ORCID: https://orcid.org/0000-0002-4181-2916)
- Kyunghye Bang (ORCID: https://orcid.org/0000-0002-5168-8197)
- Chiyoon Oum (ORCID: https://orcid.org/0000-0002-4264-7342)
- Taek Chung (ORCID: https://orcid.org/0000-0001-7567-0680)
- Chang Ho Ahn (ORCID: https://orcid.org/0000-0002-0702-0608)
- Seung Hyuck Jeon (ORCID: https://orcid.org/0000-0001-8227-9452)
- Gahee Park (ORCID: https://orcid.org/0000-0002-9599-687X)
- Kyu‐pyo Kim (ORCID: https://orcid.org/0000-0001-7848-5923)
- Chan‐Young Ock (ORCID: https://orcid.org/0000-0002-6755-9728)
- Yeong Hak Bang (ORCID: https://orcid.org/0000-0001-6544-6431)
- Baek‐Yeol Ryoo (ORCID: https://orcid.org/0000-0002-9052-833X)
- Hye Jin Choi (ORCID: https://orcid.org/0000-0001-5917-1400)
- Jinho Shin (ORCID: https://orcid.org/0000-0003-0654-7392)
- Richard S. Finn (ORCID: https://orcid.org/0000-0003-2494-2126)
- Hyung‐Don Kim (ORCID: https://orcid.org/0000-0001-9959-0642)
- Changhoon Yoo (ORCID: https://orcid.org/0000-0002-1451-8455)
- Seulki Kim (ORCID: https://orcid.org/0000-0001-5505-1022)
- Jae Ho Jeong (ORCID: https://orcid.org/0000-0002-8749-2612)
- Dong Ki Lee (ORCID: https://orcid.org/0000-0002-2830-7640)
Institutions
- Ulsan College (KR)
- Korea Advanced Institute of Science and Technology (KR)
- University of California, Los Angeles (US)
- Yonsei University (KR)
- Samsung (South Korea) (KR)
- Luther University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Konkuk University Medical Center (KR)
- Lutronic (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1265
- Citations
- 17
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.74
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Celgene
- Exelixis
- Celltrion
- Lunit
- Eisai
- Asan Institute for Life Sciences, Asan Medical Center
- Servier
- Ipsen
- Genentech
- Daiichi Sankyo Europe