Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Neuroinflammation within the contralateral hemisphere can be detected with TSPO-PET imaging and associates with poor outcome in patients with newly diagnosed glioblastoma. The molecular signature of remote neuroinflammation promotes the evaluation of immunomodulatory strategies in patients with detrimental whole brain inflammation as reflected by high TSPO expression.
Authors
- J. C. Tonn (ORCID: https://orcid.org/0009-0004-1756-423X)
- Sabrina V. Kirchleitner (ORCID: https://orcid.org/0000-0001-6864-3369)
- Matthias Prestel (ORCID: https://orcid.org/0000-0002-1096-6285)
- Zeynep Ilgin Kolabas (ORCID: https://orcid.org/0000-0002-0672-681X)
- Jens Blobner (ORCID: https://orcid.org/0000-0002-8539-8745)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Leonie Hoermann (ORCID: https://orcid.org/0009-0006-9074-3474)
- Louisa von Baumgarten (ORCID: https://orcid.org/0000-0002-6634-0927)
- Artem Zatcepin (ORCID: https://orcid.org/0000-0002-0224-088X)
- Sophia Stoecklein (ORCID: https://orcid.org/0000-0003-0325-4674)
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Nathalie L. Albert (ORCID: https://orcid.org/0000-0003-0953-7624)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Sabina Tahirović (ORCID: https://orcid.org/0000-0003-4403-9559)
- Ali Ertürk (ORCID: https://orcid.org/0000-0001-5163-5100)
- Adrien Holzgreve (ORCID: https://orcid.org/0000-0002-9566-8438)
- Selin Ulukaya (ORCID: https://orcid.org/0009-0000-3035-3155)
- Karin Wind-Mark (ORCID: https://orcid.org/0000-0002-5461-1873)
- Ha Eun Park (ORCID: https://orcid.org/0009-0002-1872-128X)
- Stefanie Quach (ORCID: https://orcid.org/0000-0003-2914-3649)
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Lea H. Kunze
- Viktoria Ruf
- Lena Kaiser (ORCID: https://orcid.org/0000-0002-2084-5858)
- Niklas Thon (ORCID: https://orcid.org/0000-0003-0011-5281)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Laura M. Bartos (ORCID: https://orcid.org/0009-0007-6158-319X)
- Valerio Zenatti
- Adrian Zounek (ORCID: https://orcid.org/0000-0001-8765-1276)
- Sibylle Ilse Ziegler (ORCID: https://orcid.org/0000-0002-5321-4817)
- Markus J. Riemenschneider (ORCID: https://orcid.org/0000-0002-3742-2982)
- Mattes Groß
- Sebastian T. Kunte
- M. Hartel
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- German Center for Neurodegenerative Diseases (DE)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- University Hospital Regensburg (DE)
- Munich Cluster for Systems Neurology (DE)
- Imperial College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1563
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Friedrich-Baur-Stiftung
- Medizinischen Fakultät, Ludwig-Maximilians-Universität München