Impact of exercise and fasting on mitochondrial regulators in human muscle
Our data indicate that acute HIIE stimulates increases in <i>NR4A1</i> and <i>PGC-1α</i> and decreases in <i>TFEB</i> mRNA expression in human skeletal muscle. Additionally, a short term (8 h) fast reduced the mRNA expression of the transcriptional regulators <i>NR4A1</i> and <i>NR1D1</i> - potentially as a mechanism of decreasing mitochondrial biogenesis to reduce energy expenditure during a period of restricted energy availability.
Authors
- Craig A. Simpson
- Hashim Islam (ORCID: https://orcid.org/0000-0002-7145-0522)
- Eveline Soares Menezes (ORCID: https://orcid.org/0000-0002-9326-7200)
- Chris McGlory (ORCID: https://orcid.org/0000-0003-4853-4960)
- Benjamin B. Arhen
- Brendon J. Gurd (ORCID: https://orcid.org/0000-0002-4008-7927)
Institutions
- University of British Columbia (CA)
- Queen's University (CA)
- Okanagan University College (CA)
Publication Details
- Journal
- Translational Exercise Biomedicine
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1515/teb-2024-0014
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Natural Sciences and Engineering Research Council of Canada