Introducing effective genes in lymph node metastasis of breast cancer patients using SHAP values based on the mRNA expression data
The prominent identified mRNAs including GDF5, BAHCC1, LCN2, FGF14-AS2, and IDH2, are implicated in lymph node metastasis. This study holds promise in elucidating a thorough insight into key candidate genes that could significantly impact the early detection and tailored therapeutic strategies for lymph node metastasis in patients with breast cancer.
Authors
- Farnaz Boostani
- Seyed Mahdi Hosseiniyan Khatibi (ORCID: https://orcid.org/0000-0002-4544-2254)
- Sepideh Zununi Vahed (ORCID: https://orcid.org/0000-0003-0179-4562)
- Yalda Rahbar Saadat
- Manijeh Emdadi
- Saeed Pirmoradi (ORCID: https://orcid.org/0000-0001-8786-8723)
- Solmaz Maleki Dizaj (ORCID: https://orcid.org/0000-0003-4759-7222)
- Mohammad Matin Alishani (ORCID: https://orcid.org/0009-0004-7748-5648)
- Bahareh Khodaei
Institutions
- Islamic Azad University, Tehran (IR)
- Tabriz University of Medical Sciences (IR)
- University of Tabriz (IR)
- Islamic Azad University, Abadan
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1371/journal.pone.0308531
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- National Institute for Medical Research Development