Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome
Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims to analyze associations of baseline and time-varying glycemic status with 3-year time-varying impulsivity in older adults at high risk of cardiovascular disease. A 3-year prospective cohort design was conducted within the PREDIMED-Plus-Cognition substudy. The total population includes 487 participants (mean age = 65.2 years; female = 50.5%) with overweight or obesity and metabolic syndrome. Insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), presence of type 2 diabetes mellitus, and type 2 diabetes control were evaluated. Impulsivity was measured using the Impulsive Behavior Scale questionnaire and various cognitive measurements. Impulsivity z-scores were generated to obtain Global, Trait, and Behavioral Impulsivity domains. Linear mixed models were used to study the longitudinal associations across baseline, 1-year, and 3-year follow-up visits. HOMA-IR was not significantly related to impulsivity. Participants with higher HbA1c levels, type 2 diabetes, and poor control of diabetes showed positive associations with the Global Impulsivity domain over time, and those with higher HbA1c levels were further related to increases in the Trait and Behavioral Impulsivity domains over the follow-up visits. These results suggest a potential positive feedback loop between impulsivity and glycemic-related dysregulation.
Authors
- Fernando Fernández‐Aranda (ORCID: https://orcid.org/0000-0002-2968-9898)
- Jordi Salas‐Salvadó (ORCID: https://orcid.org/0000-0003-2700-7459)
- Søren Dalsgaard (ORCID: https://orcid.org/0000-0003-4659-0969)
- Marta Fanlo‐Maresma (ORCID: https://orcid.org/0000-0002-5666-8726)
- Dolores Corella (ORCID: https://orcid.org/0000-0002-2366-4104)
- Andrea Álvarez‐Sala (ORCID: https://orcid.org/0000-0002-2988-1038)
- Alejandro Arias Vásquez (ORCID: https://orcid.org/0000-0002-4786-0169)
- Barbara Franke (ORCID: https://orcid.org/0000-0003-4375-6572)
- Zenaida Vázquez‐Ruiz (ORCID: https://orcid.org/0000-0002-6828-9627)
- Laura Forcano (ORCID: https://orcid.org/0000-0002-8478-1451)
- Carlos Gómez Martínez (ORCID: https://orcid.org/0000-0002-3077-6702)
- Lucía Camacho‐Barcia (ORCID: https://orcid.org/0000-0002-5989-936X)
- Jordi Júlvez (ORCID: https://orcid.org/0000-0003-0818-4003)
- Nancy Babió (ORCID: https://orcid.org/0000-0003-3527-5277)
- Rafael de la Torre (ORCID: https://orcid.org/0000-0002-6765-1866)
- Stephanie Nishi (ORCID: https://orcid.org/0000-0002-7878-5368)
- Aida Cuenca‐Royo (ORCID: https://orcid.org/0000-0001-8551-5457)
- Susanna Tello
Institutions
- University of Copenhagen (DK)
- St. Michael's Hospital (CA)
- Radboud University Nijmegen (NL)
- Universitat de València (ES)
- Universitat Pompeu Fabra (ES)
- Mental Health Services (DK)
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Bellvitge University Hospital (ES)
- Copenhagen University Hospital (DK)
- Radboud University Medical Center (NL)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Navarre Institute of Health Research (ES)
- Hospital Del Mar (ES)
- Hospital Universitari Sant Joan de Reus (ES)
- Hospital del Mar Research Institute (ES)
- Unity Health Toronto
- Universitat Rovira i Virgili (ES)
- Universitat de Barcelona (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Annals of the New York Academy of Sciences
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1111/nyas.15205
- Citations
- 2
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 1.28
Funders
- “la Caixa” Foundation
- Centres de Recerca de Catalunya
- Generalitat de Catalunya
- Universitat Rovira i Virgili
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Consejería de Salud y Bienestar Social, Junta de Andalucía
- Horizon 2020 Framework Programme
- Canadian Institutes of Health Research
- Instituto de Salud Carlos III
- European Regional Development Fund