The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis
Our results indicate that pediatric UC patients have a more unstable fecal microbiota and a lower α diversity than adult patients and that the microbiota composition differs between aUC and pUC patients. These findings offer some explanation for the observed differences between pUC and aUC and indicate that individualized approaches are needed if microbiota modifications are to be used in the future treatment of UC.
Authors
- Palle Villesen (ORCID: https://orcid.org/0000-0001-7589-8781)
- Marie Vibeke Vestergaard (ORCID: https://orcid.org/0009-0006-1409-1945)
- Corinna Bang (ORCID: https://orcid.org/0000-0001-6814-6151)
- Andreas Munk Petersen (ORCID: https://orcid.org/0000-0003-0531-0553)
- Louise B. Thingholm (ORCID: https://orcid.org/0000-0002-0266-4375)
- Vibeke Wewer (ORCID: https://orcid.org/0000-0001-9116-9458)
- Thomas Bataillon (ORCID: https://orcid.org/0000-0002-4730-2538)
- Mikkel Malham (ORCID: https://orcid.org/0000-0002-6956-7676)
- Anne Line Engsbro (ORCID: https://orcid.org/0000-0001-9544-2351)
- Astrid Dempfle (ORCID: https://orcid.org/0000-0002-2618-3920)
- Christian Jakobsen (ORCID: https://orcid.org/0000-0002-1352-1871)
- Andre Franke
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- Predict (France) (FR)
- Institut für Angewandte Statistik (DE)
- Aalborg University (DK)
- University of Lübeck (DE)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1093/ibd/izae179
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Deutsche Forschungsgemeinschaft
- Aase og Ejnar Danielsens Fond
- Exzellenzclusters Entzündungsforschung