Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma
BMI correlated directly with age and leptin levels. Obese participants presented high serum levels of leptin and FTO A allele correlated with low FEV1/FVC. Larger cohorts are necessary for better elucidation of the role of adipokines and polymorphisms in the pathophysiology of asthma and obesity.
Authors
- Luís Cristóvão Pôrto (ORCID: https://orcid.org/0000-0003-1499-1821)
- Marta Machado (ORCID: https://orcid.org/0000-0002-7312-5010)
- Jeane de Souza Nogueira (ORCID: https://orcid.org/0000-0002-4952-2278)
- José Roberto Lapa e Silva (ORCID: https://orcid.org/0000-0003-3116-0253)
- Clemax Couto Sant’Anna (ORCID: https://orcid.org/0000-0001-8732-8065)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Fundação Técnico Educacional Souza Marques (BR)
Publication Details
- Journal
- Jornal de Pediatria
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1016/j.jped.2024.07.006
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior