Surface plasmon localization-based Raman spectroscopy on nanohole arrays with particle manipulation

Localized surface plasmon was formed with plasmonic nanohole arrays for measurement of the Raman spectrum in polystyrene beads. For the selective acquisition of enhanced Raman signals, we used the surface-enhanced Raman spectroscopy (SERS) system employing particle manipulation within the electrode chip. This integration involves the amalgamation of metal nanostructures and microelectrodes to assess the electrophysiological characteristics of microparticles. The manipulation of particle movement, contingent upon their electrical properties such as conductivity and permittivity, can be controlled through modulation of the frequency of the applied alternating current field. In our integrated system, Raman spectroscopy can be conducted with enhanced intensity. Real-time measurement of enhanced Raman scattering is achieved by controlling the direction of force exerted on single particle and selectively trapping it on the nanostructured surfaces.