Nickel- and Photocatalytic Enantioselective Alkylation of α-Amino C(sp3)–H Bonds

Significance:The authors report the nickel and photoredox co-catalyzed enantioselective coupling of -amino C-H bonds and redox active esters (RAEs).The reaction proceeds via the generation and coupling of two different alkyl radicals.The enantioselectivity of the reaction remained very high even when the groups were of similar steric bulk.The authors also showed the RAEs could be generated in situ resulting in similar yields and ee values.